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The peptide works by binding to GHRH receptors on somatotroph cells in the anterior pituitary gland, amplifying the natural growth hormone-releasing hormone signal and increasing both the amplitude and duration of growth hormone pulses

However, a significant elevation in the expression of androgen receptor protein was observed in fish treated with 30 g of IPA

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In a double-blind crossover trial conducted by Ghayour-Mobarhan, 1 g/day of curcumin administered for 30 days reduced anxiety scores in obese adults, though no significant effect was observed on depressive symptoms (147)